The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028
Abstract As a form of skin cancer, melanoma’s incidence rate is continuing to rise globally. Therefore, there is an urgent need to find new agents to improve survival in melanoma patients. Isoflavones, a class of phytoestrogens, are primarily found in soy and other legumes. Cumulating evidence demon...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00370-6 |
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| author | Cheng Liang Jianfu Jiang Jinkai Li Xiao Lin Wenjun Huang Keng Po Lai Jian Chen |
| author_facet | Cheng Liang Jianfu Jiang Jinkai Li Xiao Lin Wenjun Huang Keng Po Lai Jian Chen |
| author_sort | Cheng Liang |
| collection | DOAJ |
| description | Abstract As a form of skin cancer, melanoma’s incidence rate is continuing to rise globally. Therefore, there is an urgent need to find new agents to improve survival in melanoma patients. Isoflavones, a class of phytoestrogens, are primarily found in soy and other legumes. Cumulating evidence demonstrates that isoflavones exhibits significant anti-tumor properties and is beneficial for the prevention and treatment of melanoma. In the present study, we aim to investigate the anti-melanoma role of tricholoma isoflavone derivative CA028. By using in vitro melanoma cell line models, A375 and A2058 and in vivo xenograft mouse model, our results indicate that melanoma proliferation, migration, and invasion are attenuated following CA028 treatment. In addition, the treatment of CA028 induced cell apoptosis of melanoma. Finally, we addressed the mechanism of CA028 against melanoma by comparative transcriptomic analysis. The results of gene ontology highlighted the involvement of CA028’s targets in the cell proliferation, cell apoptosis, and migration ability of melanoma cells. Furthermore, Ingenuity Pathway Analysis constructed the network involved in the apoptotic roles of CA028 through targeting p53 signaling and death receptor signaling. For the first time, our data suggested the possible use of modified isoflavone for therapeutic applications against melanoma. |
| format | Article |
| id | doaj-art-c48919fd7c5d4a968e0aade5b5f603b2 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-c48919fd7c5d4a968e0aade5b5f603b22025-01-12T12:41:15ZengNature Portfolionpj Science of Food2396-83702025-01-019111210.1038/s41538-025-00370-6The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028Cheng Liang0Jianfu Jiang1Jinkai Li2Xiao Lin3Wenjun Huang4Keng Po Lai5Jian Chen6Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical UniversityDepartment of Digestive Oncology, Yongfu County People’s HospitalGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical UniversityDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical UniversityGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical UniversityGuangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical UniversityAbstract As a form of skin cancer, melanoma’s incidence rate is continuing to rise globally. Therefore, there is an urgent need to find new agents to improve survival in melanoma patients. Isoflavones, a class of phytoestrogens, are primarily found in soy and other legumes. Cumulating evidence demonstrates that isoflavones exhibits significant anti-tumor properties and is beneficial for the prevention and treatment of melanoma. In the present study, we aim to investigate the anti-melanoma role of tricholoma isoflavone derivative CA028. By using in vitro melanoma cell line models, A375 and A2058 and in vivo xenograft mouse model, our results indicate that melanoma proliferation, migration, and invasion are attenuated following CA028 treatment. In addition, the treatment of CA028 induced cell apoptosis of melanoma. Finally, we addressed the mechanism of CA028 against melanoma by comparative transcriptomic analysis. The results of gene ontology highlighted the involvement of CA028’s targets in the cell proliferation, cell apoptosis, and migration ability of melanoma cells. Furthermore, Ingenuity Pathway Analysis constructed the network involved in the apoptotic roles of CA028 through targeting p53 signaling and death receptor signaling. For the first time, our data suggested the possible use of modified isoflavone for therapeutic applications against melanoma.https://doi.org/10.1038/s41538-025-00370-6 |
| spellingShingle | Cheng Liang Jianfu Jiang Jinkai Li Xiao Lin Wenjun Huang Keng Po Lai Jian Chen The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 npj Science of Food |
| title | The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 |
| title_full | The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 |
| title_fullStr | The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 |
| title_full_unstemmed | The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 |
| title_short | The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 |
| title_sort | anti melanoma roles and mechanisms of tricholoma isoflavone derivative ca028 |
| url | https://doi.org/10.1038/s41538-025-00370-6 |
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