Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition

Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition

Normothermic machine perfusion (NMP) is a clinical strategy to reduce renal ischemia-reperfusion injury (IRI). Optimal NMP should restore metabolism and minimize IRI induced inflammatory responses. Microdialysis was used to evaluate renal metabolism. This study aimed to assess the effect of compleme...

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Main Authors: Eline de Boer, Marina Sokolova, Neeltina M. Jager, Camilla Schjalm, Marc G. Weiss, Olav M. Liavåg, Hanno Maassen, Harry van Goor, Ebbe Billmann Thorgersen, Kristin Pettersen, Dorte Christiansen, Judith Krey Ludviksen, Bente Jespersen, Tom E. Mollnes, Henri G. D. Leuvenink, Søren E. Pischke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Transplant International
Subjects:
normothermic machine perfusion
ischemia-reperfusion injury
renal metabolism
microdialysis
inflammation
Online Access:https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13348/full
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https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13348/full

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