Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism

Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism

Despite advances in multimodal therapy approaches such as resection, chemotherapy and radiotherapy, the overall survival of patients with grade 4 glioblastoma (GBM) remains extremely poor (average survival time <2 years). Altered lipid metabolism, which increases fatty acid synthesis and thereby...

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Bibliographic Details
Main Authors: Bayan Alkotub, Lisa Bauer, Ali Bashiri Dezfouli, Khouloud Hachani, Vasilis Ntziachristos, Gabriele Multhoff, Morteza Hasanzadeh Kafshgari
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
Fenofibrate
Glioblastoma
Radiotherapy
Lipid droplets
DGAT1
GPAT4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004300
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