Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans-C. albicans infection model was previously adapted to screen for antifungal compounds. Modifications to this scre...

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Bibliographic Details
Main Authors: Ikechukwu Okoli, Jeffrey J Coleman, Emmanouil Tampakakis, W Frank An, Edward Holson, Florence Wagner, Annie L Conery, Jonah Larkins-Ford, Gang Wu, Andy Stern, Frederick M Ausubel, Eleftherios Mylonakis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007025&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007025&type=printable

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