Eco-Friendly Synthesis of Gold Nanoparticles Using Microcystis elabens for Enhanced Photothermal Therapy Applications
This study presents a strategy for the green biosynthesis of gold nanoparticles (AuNPs) using extracts from Microcystis elabens (ME-AuNPs). The synthesized ME-AuNPs exhibit photothermal responsiveness under 808[Formula: see text]nm near-infrared (NIR) laser irradiation and maintain photostability ev...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2025-01-01
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| Series: | Materials Open |
| Subjects: | |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2811086225500025 |
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| Summary: | This study presents a strategy for the green biosynthesis of gold nanoparticles (AuNPs) using extracts from Microcystis elabens (ME-AuNPs). The synthesized ME-AuNPs exhibit photothermal responsiveness under 808[Formula: see text]nm near-infrared (NIR) laser irradiation and maintain photostability even after four cycles of irradiation. Cellular uptake experiments confirmed the concentration-dependent internalization of ME-AuNPs by 4T1 cells. MTT assays demonstrated good biocompatibility of ME-AuNPs within an appropriate concentration range (0–100[Formula: see text] [Formula: see text]g/mL) in the absence of laser irradiation. Upon laser irradiation, substantial production of reactive oxygen species (ROS) is induced, promoting cell apoptosis and leading to a cell death rate of 91%. Furthermore, western blot and a series of fluorescence assays confirmed that the cytotoxic effect on cancer cells is mediated through the apoptotic pathways involving caspase 3 and Bax/Bcl-2. In conclusion, our synthesized ME-AuNPs possess favorable photothermal conversion characteristics, demonstrating excellent therapeutic efficacy and safety. |
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| ISSN: | 2811-0862 |