Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models

Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models

Non-invasive determination of amyloid-β peptide (Aβ) and tau deposition are important for early diagnosis and therapeutic intervention for Alzheimer's disease (AD) and non-AD tauopathies. In the present study, we investigated the capacity of a novel radioiodinated compound AD-DRK (123/125I-AD-D...

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Bibliographic Details
Main Authors: Xiyan Rui, Xinran Zhao, Nailian Zhang, Yuzhou Ding, Chie Seki, Maiko Ono, Makoto Higuchi, Ming-Rong Zhang, Yong Chu, Ruonan Wei, Miaomiao Xu, Chao Cheng, Changjing Zuo, Yasuyuki Kimura, Ruiqing Ni, Mototora Kai, Mei Tian, Chunyan Yuan, Bin Ji
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:NeuroImage
Subjects:
Alzheimer's disease (AD)
Amyloid
Non-Alzheimer's disease tauopathy
Single photon emission computed tomography (SPECT)
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811924004440
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