Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth

Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth

Abstract Background The typical pathological feature of pancreatic ductal adenocarcinoma (PDAC) is a significant increase in stromal reaction, leading to a hypoxic and poorly vascularized tumor microenvironment. Tumor cells undergo metabolic reprogramming, such as the Warburg effect, yet the underly...

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Bibliographic Details
Main Authors: Jichun Gu, Xi Xiao, Caifeng Zou, Yishen Mao, Chen Jin, Deliang Fu, Rongkun Li, Hengchao Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Deubiquitinating enzymes
HAUSP
Aerobic glycolysis
Glucose metabolism
Online Access:https://doi.org/10.1186/s12967-024-05962-6
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https://doi.org/10.1186/s12967-024-05962-6

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