Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease

Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease

Abstract Background Circular RNAs (circRNAs) are highly stable regulators, often accumulated in mammalian brains and thought to serve as “memory molecules” that govern the long process of aging. Mounting evidence demonstrated circRNA dysregulation in the brains of Alzheimer’s disease (AD) patients....

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Main Authors: Feng Wang, Yangping Li, Huifeng Shen, Paula Martinez-Feduchi, Xingyu Ji, Peng Teng, Siddharth Krishnakumar, Jian Hu, Li Chen, Yue Feng, Bing Yao
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Genome Medicine
Subjects:
ncRNA
circRNA
miRNA
RNA-binding protein
Neurodegeneration
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13073-024-01404-6
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https://doi.org/10.1186/s13073-024-01404-6

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