Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA

Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA

Abstract The regulation of CRISPR‒Cas activity is critical for developing advanced biotechnologies. Optical control of CRISPR‒Cas system activity can be achieved by modulation of Cas proteins or guide RNA (gRNA), but these approaches either require complex protein engineering modifications or custom...

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Main Authors: Menglu Hu, Bingni Zhang, Yuanyue Shan, Feng Cao, Yihui Wang, Weiwei Qi, Xue Wang, Yuting Shen, Xinyi Guo, Mengmeng Zhang, Tian Tian, Wei Xie, Mingfeng Zhang, Fang Liang, Duanqing Pei, Xiaoming Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61094-5
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