P55 | ENDOTHELIAL THYMIDINE PHOSPHORYLASE DEFICIENCY TRIGGERS MORPHO-FUNCTIONAL DEGE-NERATION OF ENTERIC NEURONS AND REDUCES INTESTINAL STEM CELL PROLIFERATION
The enteric nervous system (ENS) operates within a complex neurovascular niche where endothelial thymidine phosphorylase (TP) regulates vascular integrity. In mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), TP is genetically absent, resulting in enteric neuronal loss and microvascula...
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| Format: | Article |
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| Language: | English |
| Published: |
PAGEPress Publications
2025-08-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | https://www.ejh.it/ejh/article/view/4380 |
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