Synchronous childhood T-lymphoblastic lymphoma and B-cell precursor acute lymphoblastic leukemia associated with constitutional MMR deficiency syndrome –a case report

Synchronous childhood T-lymphoblastic lymphoma and B-cell precursor acute lymphoblastic leukemia associated with constitutional MMR deficiency syndrome –a case report

We present a four-year-old girl with synchronous T-cell lymphoblastic lymphoma (T-LBL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Development of two lymphoid malignancies arising from completely different cell lineages was confirmed by molecular tests. The cause of cancerogenesis in...

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Bibliographic Details
Main Authors: Joanna Bulsa, Agata Karolina Pastorczak, Joanna Taha, Wojciech Mlynarski, Łukasz Sędek, Tomasz Szczepanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
CMMRD
T-LBL
BCP-ALL
genetic cancer predisposition
synchronous cancerogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1580494/full
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Summary:We present a four-year-old girl with synchronous T-cell lymphoblastic lymphoma (T-LBL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Development of two lymphoid malignancies arising from completely different cell lineages was confirmed by molecular tests. The cause of cancerogenesis in this patient was a genetic predisposition resulting from mismatch repair deficiency syndrome (CMMRD). Herein, we present the fatal course of the disorder, challenging treatment decisions and need for special approach to the patients with CMMRD-associated malignant proliferation.
ISSN:2234-943X

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