The correlation of HLA-A in Thai EGFR-mutated advanced non-small cell lung cancer, outcome, and tumor microenvironment

The correlation of HLA-A in Thai EGFR-mutated advanced non-small cell lung cancer, outcome, and tumor microenvironment

Abstract Previously reported HLA class I correlated with the outcome of early-stage non-small cell lung cancer (NSCLC) in the Japanese population. The binding affinity capability of the EGFR mutation peptide and various HLA-A subtypes could explain this. We conducted a prospective cohort study to ex...

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Main Authors: Nicha Zungsontiporn, Korakot Srianuwattipong, Sakun Santisukwongchote, Piyada Sitthideatphaiboon, Poonchavist Chantranuwat, Chatchawit Aporntewan, Chanida Vinayanuwattikun
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Tumor immune microenvironment
Advanced or recurrence NSCLC
EGFR mutations
HLA typing
EGFR TKIs
Online Access:https://doi.org/10.1038/s41598-025-16365-y
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https://doi.org/10.1038/s41598-025-16365-y

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