Mechanism research of Punicalagin in treating representative strains of enterovirus A and B types based on systems pharmacology and experimental validation

Mechanism research of Punicalagin in treating representative strains of enterovirus A and B types based on systems pharmacology and experimental validation

Abstract Background Enteroviruses (EVs), particularly types A (e.g., EV-A71) and B (e.g., CVB3), cause severe complications in vulnerable populations. Limited vaccines and no antivirals underscore the need for broad-spectrum therapies. Punicalagin, a natural anti-inflammatory compound, was investiga...

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Main Authors: Yuwei Liu, Jing Chen, Nana Du, Min Zhao, Yi Zhao, Ping Wu, Likai Ji, Shixing Yang, Xiaochun Wang, Quan Shen, Xiaodan Zhang, Songyi Ning, Hongfeng Yang, Wen Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
Enterovirus
Punicalagin
Co-treatment of different diseases
Anti-apoptosis
Anti-inflammation
Online Access:https://doi.org/10.1186/s12985-025-02845-0
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https://doi.org/10.1186/s12985-025-02845-0

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