Angpt2/Tie2 autostimulatory loop controls tumorigenesis

Angpt2/Tie2 autostimulatory loop controls tumorigenesis

Abstract Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non‐resectable neoplasms associated with frequent relapses and significant comorbidities. As the current therapies of NF‐PitNETs often fail, new therapeutic targets are needed. The observation that circulating angiop...

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Main Authors: Ninelia Minaskan Karabid, Tobias Wiedemann, Sebastian Gulde, Hermine Mohr, Renu Chandra Segaran, Julia Geppert, Maria Rohm, Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Donna Pauler Ankerst, Yiyao Chen, Rickmer Braren, Georg Kaissis, Franz Schilling, Mathias Schillmaier, Graeme Eisenhofer, Stephan Herzig, Federico Roncaroli, Jürgen B Honegger, Natalia S Pellegata
Format: Article
Language:English
Published: Springer Nature 2022-03-01
Series:EMBO Molecular Medicine
Subjects:
angiopoietin 2
anti‐angiopoietin biologicals
PitNETs
tumor/endothelial cell crosstalk
tumor‐bound Tie2
Online Access:https://doi.org/10.15252/emmm.202114364
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https://doi.org/10.15252/emmm.202114364

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