Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems

Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems

Abstract This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) to solve the limited oral bioavailability problem of apigenin, a bioactive flavonoid. Apigenin-loaded SNEDDS consisting of Gelucire 44/14, Tween 80, and PEG 400 in the mass ratios of 25:37.5:37.5 and 30:35:35 we...

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Bibliographic Details
Main Authors: Vilasinee Hirunpanich Sato, Hitoshi Sato, Manaw Sangfuang, Jannarin Nontakham, Varaporn Buraphacheep Junyaprasert, Veerawat Teeranachaideekul, Boontida Morakul
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Apigenin
Self-nanoemulsifying drug delivery systems (SNEDDS)
Caco-2
Permeability
Pharmacokinetics
Bioavailability
Online Access:https://doi.org/10.1038/s41598-024-84063-2
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