Improved mRNA-based RSV vaccine with PreF forming enveloped virus-like particles

Improved mRNA-based RSV vaccine with PreF forming enveloped virus-like particles

Abstract Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and the elderly. However, natural infection fails to induce durable immune protection, and existing mRNA vaccines for older adults exhibit limited long-term efficacy. We developed an antigen engineering strategy...

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Main Authors: Pengdi Chai, Yi Shi, Xiaoyan Li, Mengyao Yang, Xiafei Liu, Mei Liu, Junjie Yu, Xiaoxuan Yin, Dongwei Li, Ke Li, Xiangyu Kong, Qin Zhang, Hong Wang, Xiaoman Sun, Jinsong Li, Lili Li, Dandi Li, Lili Pang, Xuancheng Lu, Zhaojun Duan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01205-x
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https://doi.org/10.1038/s41541-025-01205-x

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