<i>N</i>-Acetylcysteine Treatment Restores the Protective Effect of Heart Ischemic Postconditioning in a Murine Model in the Early Stages of Atherosclerosis

<i>N</i>-Acetylcysteine Treatment Restores the Protective Effect of Heart Ischemic Postconditioning in a Murine Model in the Early Stages of Atherosclerosis

<b>Background/Objectives:</b> Ischemic postconditioning (IP) is a well-established intervention that mitigates this damage by activating endogenous cardioprotective pathways. However, the presence of comorbidities such as dyslipidemia can disrupt these protective mechanisms and abolish t...

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Main Authors: Tamara Zaobornyj, Virginia Perez, Georgina Ossani, Tamara Mazo, Eugenia Godoy, Jorge Godoy, Yohana Yanaje, Camila Musci-Ferrari, Mario Contin, Valeria Tripodi, Magali Barchuk, Gabriela Berg, Ricardo J. Gelpi, Martin Donato, Veronica D’Annunzio
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
ischemia/reperfusion injury
ischemic postconditioning
high-fat diet
redox balance
<i>N</i>-acetylcysteine
Online Access:https://www.mdpi.com/1424-8247/18/7/1014
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