Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach

Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach

Abstract Background Amyotrophic lateral sclerosis (ALS), an alarming neurodegenerative disorder, induces muscle atrophy and motor deterioration. The current treatments exhibit limited improvement in survival rates. Thus, we here attempted to identify crucial genetic biomarkers through transcriptome...

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Bibliographic Details
Main Authors: Navid Kashani, Amir Sabbaghian, Fatemeh EmamiPari, Mohammad Khalili Gorjimahalleh, Mahdi Aalikhani
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Amyotrophic lateral sclerosis
Drug repurposing
Molecular docking
RNA-sequencing
Online Access:https://doi.org/10.1186/s43042-025-00648-0
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