Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39

Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39

ABSTRACT Background Muscle atrophy is a severe complication of diabetes, with autophagy playing a critical role in its progression. Zinc has been shown to alleviate hyperglycaemia and several diabetes‐related complications, but its direct role in mediating diabetic muscle atrophy remains unclear. Th...

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Bibliographic Details
Main Authors: Xing Yu, Xiaojun Chen, Weibin Wu, Huibin Tang, Yunyun Su, Guili Lian, Yujie Zhang, Liangdi Xie
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
autophagy
GPR39
muscle atrophy
SIRT1/FoxO1
zinc
Online Access:https://doi.org/10.1002/jcsm.13771
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https://doi.org/10.1002/jcsm.13771

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