胃癌组织中血管内皮生长因子-C 及其受体-3 的表达与意义
【目的】探讨血管内皮生长因子-C(vascularendothelialgrowthfactor-C,VEGF-C)其受体-3(vascularendothelialgrowthfactorreceptor-3,VEGFR-3)与胃癌临床病理因素的关系。【方法】应用免疫组织化学(SP)方法测定胃癌及胃良性病变中VEGF-C与VEGFR-3表达,计数(200×视野下淋巴管数密度(numberdensi-tyoflymphvessel,/200×nDLV)。【结果】VEGF-C阳性率胃癌组60.00%,胃良性病变组15.00%(P=0.000);淋巴结转移组68.97%,无淋巴结转移组36.36%...
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2004-01-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43584919/ |
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| Summary: | 【目的】探讨血管内皮生长因子-C(vascularendothelialgrowthfactor-C,VEGF-C)其受体-3(vascularendothelialgrowthfactorreceptor-3,VEGFR-3)与胃癌临床病理因素的关系。【方法】应用免疫组织化学(SP)方法测定胃癌及胃良性病变中VEGF-C与VEGFR-3表达,计数(200×视野下淋巴管数密度(numberdensi-tyoflymphvessel,/200×nDLV)。【结果】VEGF-C阳性率胃癌组60.00%,胃良性病变组15.00%(P=0.000);淋巴结转移组68.97%,无淋巴结转移组36.36%(P=0.008);低分化组72.73%,高+中分化组44.44%(P=0.010);伴有远处转移组100%,不伴有远处转移组53.62%(P=0.02);pTNM分期Ⅰ+Ⅱ组43.75%,Ⅲ+Ⅳ组70.83%(P=0.015)。淋巴管数密度(显微镜下每200×视野)胃癌组为(5.800±2.3189),胃良性病变组为(2.3800±0.4629)(P=0.000);淋巴结转移组为(6.9483±1.5831),无淋巴结转移组为(2.7727±0.4289)(P=0.000);低分化组为(7.6818±0.9829),高+中分化组为(3.500±1.0282)(P=0.000);pTNM分期,Ⅰ+Ⅱ组为(4.2917±1.6880),pTNM分期,Ⅲ+Ⅳ组为(8.0625±0.7594)(P=0.000)。VEGF-C与淋巴管数密度相关(P=0.002)。【结论】VEGF-C刺激淋巴管生成,有利于胃癌淋巴道与远处转移。 |
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| ISSN: | 1672-3554 |