Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms

Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms

<i>CYP2D</i> enzymes engage in the synthesis of endogenous neuroactive substances (dopamine, serotonin) and in the metabolism of neurosteroids. The present work investigates the effect of iloperidone on CYP2D enzyme expression and activity in rat brains and livers. Iloperidone exerted a...

Full description

Saved in:
Bibliographic Details
Main Authors: Przemysław J. Danek, Władysława A. Daniel
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
iloperidone
prolonged administration
brain
liver
cytochrome P450 2D expression/activity
Online Access:https://www.mdpi.com/2073-4409/10/12/3472
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2073-4409/10/12/3472

Similar Items