Identifying selective PDHK inhibitors using coupled tensor matrix completion and experimental validation

Identifying selective PDHK inhibitors using coupled tensor matrix completion and experimental validation

Abstract Drug discovery often involves targeting specific members within a family of similar proteins. For example, pyruvate dehydrogenase kinase (PDHK) exists as four isozymes, which exhibit varying expression patterns across multiple tissues. Different PDHK isozymes have been implicated in conditi...

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Bibliographic Details
Main Authors: Flora Rajaei, Peter Toogood, Renju Jacob, Mason Baber, Mya Gough, Harm Derksen, Emily Wittrup, Kayvan Najarian
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Discover Artificial Intelligence
Subjects:
PDHK
Coupled tensor matrix completion
Compound-target interaction
Machine learning
Online Access:https://doi.org/10.1007/s44163-024-00202-8
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https://doi.org/10.1007/s44163-024-00202-8

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