MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?

MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?

Abstract Background White matter lesions (WML) and dilated perivascular spaces (PVS) are features of small vessel disease (SVD), commonly observed in aging and dementia, with unknown pathophysiology. Human studies have documented contrast accumulation within and in proximity of SVD-lesions. However,...

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Bibliographic Details
Main Authors: Tomas Vikner, Anders Garpebring, Cecilia Björnfot, Jan Malm, Anders Eklund, Anders Wåhlin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Fluids and Barriers of the CNS
Subjects:
MRI
Small vessel disease
White matter lesions
Perivascular spaces
Blood-brain barrier
Online Access:https://doi.org/10.1186/s12987-025-00675-4
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https://doi.org/10.1186/s12987-025-00675-4

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