Sulfoxidation of pyrimidine thioate derivatives and study their biological activities

Sulfoxidation of pyrimidine thioate derivatives and study their biological activities

Abstract In a quest to innovate biologically active molecules, the benzoylation of 4,6-dimethylpyrimidine-2-thiol hydrochloride (1) with benzoyl chloride derivatives was employed to produce a series of pyrimidine benzothioate derivatives (2–5). Subsequent sulfoxidation of these derivatives (2–5) usi...

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Bibliographic Details
Main Authors: Atif A. El-Gharably, A. A. Nassar, N. M. El-Ganzory, Khalil M. Saad-Allah, A. A. El-Barbary
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Benzothioates
Sulfonyl methanone
Sulfonothioates
Benzene sulfonothioates
Pyrimidine
Antimicrobial
Online Access:https://doi.org/10.1038/s41598-024-83050-x
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https://doi.org/10.1038/s41598-024-83050-x

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