Structural basis of a microbial trimethylamine transporter

Structural basis of a microbial trimethylamine transporter

ABSTRACT Trimethylamine (TMA), a simple trace biogenic amine resulting from the decomposition of proteins and other macromolecules, is ubiquitous in nature. It is found in the human gut as well as in various terrestrial and marine ecosystems. While the role of TMA in promoting cardiovascular disease...

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Main Authors: Chao Gao, Hai-Tao Ding, Kang Li, Hai-Yan Cao, Ning Wang, Zeng-Tian Gu, Qing Wang, Mei-Ling Sun, Xiu-Lan Chen, Yin Chen, Yu-Zhong Zhang, Hui-Hui Fu, Chun-Yang Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
Subjects:
TMA
TMA transporter
cryo-EM structure
binding mechanism
transport mechanism
Online Access:https://journals.asm.org/doi/10.1128/mbio.01914-24
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