Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis

Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis

Abstract Trimethylamine-N-oxide (TMAO) is a gut microbiome-derived metabolite of choline, L-carnitine and lecithin, abundant in animal source foods. In experimental models, higher blood TMAO levels enhance atherosclerotic cardiovascular disease (ASCVD). However in humans, most prior studies have eva...

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Main Authors: Matthew J. Budoff, Marcia C. de Oliveira Otto, Xinmin S. Li, Yujin Lee, Meng Wang, Heidi T. M. Lai, Rozenn N. Lemaitre, Alan Pratt, Wai Hong Wilson Tang, Bruce M. Psaty, David S. Siscovick, Stanley L. Hazen, Dariush Mozaffarian
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cardiovascular disease (CVD)
Major adverse cardiac events (MACE)
Myocardial infarction
Trimethylamine N-oxide (TMAO)
Nutrition
Online Access:https://doi.org/10.1038/s41598-025-05903-3
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https://doi.org/10.1038/s41598-025-05903-3

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