PDGF-BB promotes oral submucosal fibrosis by driving phenotypic transformation and autophagy in oral mucosal fibroblasts through downregulation of circHIPK3

PDGF-BB promotes oral submucosal fibrosis by driving phenotypic transformation and autophagy in oral mucosal fibroblasts through downregulation of circHIPK3

Abstract Circular RNA HIPK3 (circHIPK3), known to regulate cell proliferation, migration, transformation, and autophagy in various fibrotic conditions. However, its role has not been studied in oral submucous fibrosis (OSF). Therefore, we conducted this study to explore whether platelet-derived grow...

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Bibliographic Details
Main Authors: Huamin Zhang, Yutong Zhou, Ni Jian, Canhua Jiang, Qi Wang, Jie Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Oral submucosal fibrosis
Platelet-derived growth factor-BB
circHIPK3
YBX1
Signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-99753-8
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https://doi.org/10.1038/s41598-025-99753-8

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