Vasoplegia: A Review
Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure, sepsis, and post-cardiac surgery. In the card...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2023-08-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1245 |
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| author | Iqbal Ratnani Rohan Kumar Ochani Asim Shaikh Hafsa Nazir Jatoi |
| author_facet | Iqbal Ratnani Rohan Kumar Ochani Asim Shaikh Hafsa Nazir Jatoi |
| author_sort | Iqbal Ratnani |
| collection | DOAJ |
| description | Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure, sepsis, and post-cardiac surgery. In the cardiac cohort, multiple risk factors for vasoplegia have been identified. Several factors contribute to the pathophysiology of this condition, and various mechanisms have been proposed, including nitric oxide, adenosine, prostanoids, endothelins, the renin-angiotensin-aldosterone system, and hydrogen sulfide. Early identification and prompt management of vasoplegia is crucial to prevent development of shock. This review expands upon the different vasopressors used in management of vasoplegia, including catecholamines such as norepinephrine, dopamine, epinephrine, phenylephrine, and other agents including vasopressin, methylene blue, angiotensin II, hydroxocobalamin, vitamin C, thiamine, and corticosteroids (ie, hydrocortisone). It also emphasizes the importance of conducting further research and making advancements in treatment regimens for vasoplegia. |
| format | Article |
| id | doaj-art-c037de8949f84c68b4be23db114f10d0 |
| institution | Kabale University |
| issn | 1947-6108 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-c037de8949f84c68b4be23db114f10d02025-08-20T03:47:06ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082023-08-01194384710.14797/mdcvj.12451222Vasoplegia: A ReviewIqbal Ratnani0https://orcid.org/0000-0002-1168-3041Rohan Kumar Ochani1https://orcid.org/0000-0002-0075-2267Asim Shaikh2https://orcid.org/0000-0001-6984-9465Hafsa Nazir Jatoi3https://orcid.org/0000-0002-6380-1687Methodist DeBakey Heart & Vascular Center, Houston Methodist, Houston, TexasSUNY Upstate Medical University, Syracuse, New YorkAga Khan University, KarachiDow University of Health Sciences, KarachiVasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure, sepsis, and post-cardiac surgery. In the cardiac cohort, multiple risk factors for vasoplegia have been identified. Several factors contribute to the pathophysiology of this condition, and various mechanisms have been proposed, including nitric oxide, adenosine, prostanoids, endothelins, the renin-angiotensin-aldosterone system, and hydrogen sulfide. Early identification and prompt management of vasoplegia is crucial to prevent development of shock. This review expands upon the different vasopressors used in management of vasoplegia, including catecholamines such as norepinephrine, dopamine, epinephrine, phenylephrine, and other agents including vasopressin, methylene blue, angiotensin II, hydroxocobalamin, vitamin C, thiamine, and corticosteroids (ie, hydrocortisone). It also emphasizes the importance of conducting further research and making advancements in treatment regimens for vasoplegia.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1245vasoplegiavasodilatory shockseptic shockvasopressorscatecholamines |
| spellingShingle | Iqbal Ratnani Rohan Kumar Ochani Asim Shaikh Hafsa Nazir Jatoi Vasoplegia: A Review Methodist DeBakey Cardiovascular Journal vasoplegia vasodilatory shock septic shock vasopressors catecholamines |
| title | Vasoplegia: A Review |
| title_full | Vasoplegia: A Review |
| title_fullStr | Vasoplegia: A Review |
| title_full_unstemmed | Vasoplegia: A Review |
| title_short | Vasoplegia: A Review |
| title_sort | vasoplegia a review |
| topic | vasoplegia vasodilatory shock septic shock vasopressors catecholamines |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1245 |
| work_keys_str_mv | AT iqbalratnani vasoplegiaareview AT rohankumarochani vasoplegiaareview AT asimshaikh vasoplegiaareview AT hafsanazirjatoi vasoplegiaareview |