Matrix metalloproteinase-9 mediates endothelial glycocalyx degradation and correlates with severity of hemorrhagic fever with renal syndrome

Matrix metalloproteinase-9 mediates endothelial glycocalyx degradation and correlates with severity of hemorrhagic fever with renal syndrome

Summary: Hemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus (PUUV) leads to vascular dysfunction contributing to acute kidney injury (AKI) and pulmonary complications. The endothelial glycocalyx (eGLX) is crucial for vascular integrity, and its degradation may exacerbate disease se...

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Main Authors: Chloé Jacquet, Rasmus Gustafsson, Ankit Kumar Patel, Magnus Hansson, Gregory Rankin, Fouzia Bano, Julia Wigren Byström, Anders Blomberg, Johan Rasmuson, Simon Satchell, Therese Thunberg, Clas Ahlm, Marta Bally, Anne-Marie Fors Connolly
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
biochemistry
microbiology
cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225015238
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http://www.sciencedirect.com/science/article/pii/S2589004225015238

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