Metabolic memory underlying minimal residual disease in breast cancer

Metabolic memory underlying minimal residual disease in breast cancer

Abstract Tumor relapse from treatment‐resistant cells (minimal residual disease, MRD) underlies most breast cancer‐related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, we integrated multi‐omics data from a tractable organoid system with a...

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Main Authors: Ksenija Radic Shechter, Eleni Kafkia, Katharina Zirngibl, Sylwia Gawrzak, Ashna Alladin, Daniel Machado, Christian Lüchtenborg, Daniel C Sévin, Britta Brügger, Kiran R Patil, Martin Jechlinger
Format: Article
Language:English
Published: Springer Nature 2021-10-01
Series:Molecular Systems Biology
Subjects:
glycolysis
metabolic modeling
multi‐omics integration
oncogenic memory
organoids
Online Access:https://doi.org/10.15252/msb.202010141
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https://doi.org/10.15252/msb.202010141

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