Colistin enhances caspofungin antifungal efficacy against Aspergillus fumigatus by modulating calcium homeostasis and stress responses

Colistin enhances caspofungin antifungal efficacy against Aspergillus fumigatus by modulating calcium homeostasis and stress responses

Abstract Fungal infections cause more than 2.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, by screening a collection of 5297 compounds derived from three chemical libraries, we demonstrate t...

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Main Authors: Laura Cristina García Carnero, Xingyue Li, Patrícia Alves de Castro, Camila Figueiredo Pinzan, Jonatas Erick Maimoni Campanella, Iran Malavazi, Mami Yoshimura, Luis Alberto Vega Isuhuaylas, Yoko Yashiroda, Charles Boone, Nir Osherov, Sara Fallah, Taylor Davie, Nicole Robbins, Leah Cowen, Ling Lu, Thaila Fernanda dos Reis, Gustavo H. Goldman
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60991-z
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https://doi.org/10.1038/s41467-025-60991-z

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