Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles
Development of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. In this study, a novel method is presented for fabricating crosslinked polydopamine particles (XPDPs) using a water...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024174105 |
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| author | Majid Moussaei Ebrahim Tajik Vahid Haddadi-Asl S. Ali Mazloumi Helia Heydarinasab Elahe Abdollahi Fatemeh Haj-Sadeghi Hanie Ahmadi Mohammad Reza Gholizadeh |
| author_facet | Majid Moussaei Ebrahim Tajik Vahid Haddadi-Asl S. Ali Mazloumi Helia Heydarinasab Elahe Abdollahi Fatemeh Haj-Sadeghi Hanie Ahmadi Mohammad Reza Gholizadeh |
| author_sort | Majid Moussaei |
| collection | DOAJ |
| description | Development of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. In this study, a novel method is presented for fabricating crosslinked polydopamine particles (XPDPs) using a water/water Pickering emulsion system. The emulsion is composed of poly(ethylene glycol) and dextran, stabilized by polydopamine (PDA) particles. This method yields XPDPs with a mean particle size of 0.55 μm, significantly smaller than PDA particles (1.025 μm), resulting in a higher surface area favorable for drug loading. The adsorption mechanism involves electron sharing and covalent bonding between the carrier and drug molecules. The adsorption, release, and drug delivery kinetics of the XPDPs are compared with those of the non-crosslinked PDA particles. The results demonstrate that XPDPs exhibit improved adsorption properties due to their crosslinked structure and increased positive charge due to presence of secondary amines. During a 28-h period, curcumin release from PDA declines from around 80 %–40 %, while for XPDA, it decreases from approximately 60 %–35 % as the pH shifts from 7.4 to 5. While PDA particles display a burst release profile, XPDPs show a more gradual and sustained release, attributed to their enhanced structural stability. Molecular simulations were conducted to estimate the solubility parameters, confirming the compatibility between PDA and dextran for effective drug loading. |
| format | Article |
| id | doaj-art-bfc3e3bd24e1421c9ac2341db4e9ddd2 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-bfc3e3bd24e1421c9ac2341db4e9ddd22025-01-17T04:51:05ZengElsevierHeliyon2405-84402025-01-01111e41379Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particlesMajid Moussaei0Ebrahim Tajik1Vahid Haddadi-Asl2S. Ali Mazloumi3Helia Heydarinasab4Elahe Abdollahi5Fatemeh Haj-Sadeghi6Hanie Ahmadi7Mohammad Reza Gholizadeh8Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranCorresponding author.; Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, IranDevelopment of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. In this study, a novel method is presented for fabricating crosslinked polydopamine particles (XPDPs) using a water/water Pickering emulsion system. The emulsion is composed of poly(ethylene glycol) and dextran, stabilized by polydopamine (PDA) particles. This method yields XPDPs with a mean particle size of 0.55 μm, significantly smaller than PDA particles (1.025 μm), resulting in a higher surface area favorable for drug loading. The adsorption mechanism involves electron sharing and covalent bonding between the carrier and drug molecules. The adsorption, release, and drug delivery kinetics of the XPDPs are compared with those of the non-crosslinked PDA particles. The results demonstrate that XPDPs exhibit improved adsorption properties due to their crosslinked structure and increased positive charge due to presence of secondary amines. During a 28-h period, curcumin release from PDA declines from around 80 %–40 %, while for XPDA, it decreases from approximately 60 %–35 % as the pH shifts from 7.4 to 5. While PDA particles display a burst release profile, XPDPs show a more gradual and sustained release, attributed to their enhanced structural stability. Molecular simulations were conducted to estimate the solubility parameters, confirming the compatibility between PDA and dextran for effective drug loading.http://www.sciencedirect.com/science/article/pii/S2405844024174105PolydopamineCurcuminControlled drug releaseMolecular simulation |
| spellingShingle | Majid Moussaei Ebrahim Tajik Vahid Haddadi-Asl S. Ali Mazloumi Helia Heydarinasab Elahe Abdollahi Fatemeh Haj-Sadeghi Hanie Ahmadi Mohammad Reza Gholizadeh Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles Heliyon Polydopamine Curcumin Controlled drug release Molecular simulation |
| title | Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles |
| title_full | Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles |
| title_fullStr | Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles |
| title_full_unstemmed | Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles |
| title_short | Achieving enhanced stabilization and controlled release of curcumin via cross-linked polydopamine particles |
| title_sort | achieving enhanced stabilization and controlled release of curcumin via cross linked polydopamine particles |
| topic | Polydopamine Curcumin Controlled drug release Molecular simulation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024174105 |
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