Access to optically active tetrafluoroethylenated amines based on [1,3]-proton shift reaction

Access to optically active tetrafluoroethylenated amines based on [1,3]-proton shift reaction

Treatment of various (R)-N-(2,2,3,3-tetrafluoropent-4-en-1-ylidene)-1-phenylethylamine derivatives with 2.4 equiv of DBU in toluene at room temperature to 50 °C for 24 h led to a smooth [1,3]-proton shift reaction with a high chirality transfer, affording the corresponding rearranged products in acc...

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Bibliographic Details
Main Authors: Yuta Kabumoto, Eiichiro Yoshimoto, Bing Xiaohuan, Masato Morita, Motohiro Yasui, Shigeyuki Yamada, Tsutomu Konno
Format: Article
Language:English
Published: Beilstein-Institut 2024-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amine
chirality transfer
[1,3]-proton shift reaction
tetrafluoroethylene fragment
Online Access:https://doi.org/10.3762/bjoc.20.233
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https://doi.org/10.3762/bjoc.20.233

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