DON affects the proliferation of zebrafish PAC2 fibroblasts by binding to ribosomes, reducing DNA replication, arresting the cell cycle and interfering with mitosis

DON affects the proliferation of zebrafish PAC2 fibroblasts by binding to ribosomes, reducing DNA replication, arresting the cell cycle and interfering with mitosis

Deoxynivalenol (DON) is a type of mycotoxin that widely contaminates aquatic feed. Although the detrimental effects of DON on fish have been investigated, the specific impacts of DON on the proliferation of zebrafish PAC2 fibroblasts remain unclear. In this study, it was found that DON significantly...

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Bibliographic Details
Main Authors: Huimin Duan, Yongsheng Tian, Zhentong Li, Aizhong Han
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Deoxynivalenol
Zebrafish PAC2 fibroblast
Cell proliferation
Toxicity mechanism
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325011212
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