Engineering a DYRK1B R102C mutation: insights into metabolic syndrome pathogenesis through lentiviral gene delivery

Engineering a DYRK1B R102C mutation: insights into metabolic syndrome pathogenesis through lentiviral gene delivery

Background: A rare heterozygous DYRK1B mutation (R102C) recently linked to a familial form of metabolic syndrome prompted this study to introduce the R102C mutation into the mouse DYRK1B gene, utilizing recombinant lentiviruses for long-term gene expression. Methods: In the present fundamental study...

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Bibliographic Details
Main Authors: Afrooz Daneshparvar, Iman Jamhiri, Vahid Razban, Jafar Fallahi, Nasrin Hamidizadeh, Behnam Moghtaderi, Mehdi Dianatpour
Format: Article
Language:English
Published: Golestan University of Medical Sciences 2024-07-01
Series:Medical Laboratory Journal
Subjects:
dyrk1b protein
human
metabolic syndrome
mutagenesis
cloning
organism
lentivirus
genetic vectors
Online Access:http://mlj.goums.ac.ir/article-1-1763-en.pdf
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http://mlj.goums.ac.ir/article-1-1763-en.pdf

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