Physiologically based pharmacokinetic modeling of drug–drug interactions between ritonavir‐boosted atazanavir and rifampicin in pregnancy

Physiologically based pharmacokinetic modeling of drug–drug interactions between ritonavir‐boosted atazanavir and rifampicin in pregnancy

Abstract Ritonavir‐boosted atazanavir (ATV/r) and rifampicin are mainstays of second‐line antiretroviral and multiple anti‐TB regimens, respectively. Rifampicin induces CYP3A4, a major enzyme involved in atazanavir metabolism, causing a drug–drug interaction (DDI) which might be exaggerated in pregn...

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Main Authors: Shakir Atoyebi, Maiara Camotti Montanha, Ritah Nakijoba, Catherine Orrell, Henry Mugerwa, Marco Siccardi, Paolo Denti, Catriona Waitt
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13268
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https://doi.org/10.1002/psp4.13268

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