Decoding TDP-43: the molecular chameleon of neurodegenerative diseases

Decoding TDP-43: the molecular chameleon of neurodegenerative diseases

Abstract TAR DNA-binding protein 43 (TDP-43) has emerged as a critical player in neurodegenerative disorders, with its dysfunction implicated in a wide spectrum of diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD). This com...

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Bibliographic Details
Main Authors: Jixiang Zeng, Chunmei Luo, Yang Jiang, Tao Hu, Bixia Lin, Yuanfang Xie, Jiao Lan, Jifei Miao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Acta Neuropathologica Communications
Subjects:
TDP-43
neurodegeneration
RNA metabolism
chromatin regulation
cryptic exons
mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s40478-024-01914-9
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https://doi.org/10.1186/s40478-024-01914-9

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