<i>Trichophyton indotineae Erg1</i><sup>Ala448Thr</sup> Strain Expressed Constitutively High Levels of Sterol 14-α Demethylase <i>Erg11B</i> mRNA, While Transporter <i>MDR3</i> and <i>Erg11A</i> mRNA Expression Was Induced After Addition of Short Chain Azoles

<i>Trichophyton indotineae Erg1</i><sup>Ala448Thr</sup> Strain Expressed Constitutively High Levels of Sterol 14-α Demethylase <i>Erg11B</i> mRNA, While Transporter <i>MDR3</i> and <i>Erg11A</i> mRNA Expression Was Induced After Addition of Short Chain Azoles

<i>Trichophyton indotineae</i> is an emerging pathogen causing recalcitrant skin infections and exhibiting multiple resistances to azoles and allylamines. Squalene epoxidase <i>erg1</i><sup>Ala448Thr</sup> mutants often show association with azole resistance. RT-P...

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Bibliographic Details
Main Authors: Nadine Berstecher, Anke Burmester, Deborah Maria Gregersen, Jörg Tittelbach, Cornelia Wiegand
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Journal of Fungi
Subjects:
ergosterol biosynthesis
sterol 14-α demethylase
<i>Erg11</i>
squalene epoxidase
<i>Erg1</i>
MDR transporter
Online Access:https://www.mdpi.com/2309-608X/10/11/731
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