Neuroprotective role of sialic-acid-binding immunoglobulin-like lectin-11 in humanized transgenic mice

Neuroprotective role of sialic-acid-binding immunoglobulin-like lectin-11 in humanized transgenic mice

Brain aging is a chronic process linked to inflammation, microglial activation, and oxidative damage, which can ultimately lead to neuronal loss. Sialic acid-binding immunoglobulin-like lectin-11 (SIGLEC-11) is a human lineage-specific microglial cell surface receptor that recognizes α-2-8-linked ol...

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Bibliographic Details
Main Authors: Tawfik Abou Assale, Negin Afrang, Jannis Wissfeld, German Cuevas-Rios, Christine Klaus, Bettina Linnartz-Gerlach, Harald Neumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Neuroscience
Subjects:
Siglec-11
aging
microglia
neurodegeneration
neuroinflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1504765/full
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https://www.frontiersin.org/articles/10.3389/fnins.2024.1504765/full

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