Evaluation and interpretation of DTI-ALPS, a proposed surrogate marker for glymphatic clearance, in a large population-based sample

Evaluation and interpretation of DTI-ALPS, a proposed surrogate marker for glymphatic clearance, in a large population-based sample

Abstract Background The diffusion tensor imaging along perivascular spaces index (DTI-ALPS), which measures diffusivity in the perivascular spaces along the medullary veins, has gained popularity and controversy as a surrogate marker of glymphatic clearance. The goal of this work is to automatically...

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Bibliographic Details
Main Authors: Siddhartha Satpathi, Robert I. Reid, Scott A. Przybelski, Sheelakumari Raghavan, Petrice M. Cogswell, Nolan K. Meyer, Val J. Lowe, Jeffrey L. Gunter, Ronald C. Petersen, Clifford R. Jack, Jonathan Graff-Radford, Prashanthi Vemuri
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
DTI-ALPS
Vascular dysfunction
Amyloid deposition
Online Access:https://doi.org/10.1186/s13195-025-01842-3
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https://doi.org/10.1186/s13195-025-01842-3

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