Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine
Recent research has demonstrated the efficacy of traditional Chinese medicine (TCM) and its active compounds in combating cancer, leading to an increasing utilization of TCM as adjunctive therapy in clinical oncology. However, the optimal dosage of TCM remains unclear, and excessive use may result i...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1485007/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553407545966592 |
|---|---|
| author | Guanhua Fang Guanhua Fang Yanming Shen Xinyue Gao Lele Yang An Zhu Dongshan Liao Dongshan Liao |
| author_facet | Guanhua Fang Guanhua Fang Yanming Shen Xinyue Gao Lele Yang An Zhu Dongshan Liao Dongshan Liao |
| author_sort | Guanhua Fang |
| collection | DOAJ |
| description | Recent research has demonstrated the efficacy of traditional Chinese medicine (TCM) and its active compounds in combating cancer, leading to an increasing utilization of TCM as adjunctive therapy in clinical oncology. However, the optimal dosage of TCM remains unclear, and excessive use may result in cardiotoxicity, which poses a significant health concern for patients undergoing systemic treatment. Therefore, elucidating the underlying mechanisms of cytotoxicity induced by TCM can provide valuable insights for clinical management. In this study, we employed a comprehensive bioinformatics analysis to present sequencing data obtained from AC16 myocardial cells treated with two bioactive derived from botanical drugs: Matrine and Evodiamine. We aim to investigate the dysregulated signaling pathways associated with cardiotoxicity induced by these compounds. Based on our sequencing results, we observed consistent patterns of gene expression and epitranscriptome regulation (m6A and A-to-I modifications) across various drugs-treated AC16 cells when analyzed using KEGG pathway enrichment and gene ontology analyses. Furthermore, m6A writers VIRMA and A-to-I writers ADARB1 is consistent target of Evodiamine and Matrine. In general, our findings suggest that different Chinese botanical drugs induced cardiotoxicity may share common therapeutic strategies. |
| format | Article |
| id | doaj-art-bed9446f24da4ae5b660f142fa8e9cd7 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-bed9446f24da4ae5b660f142fa8e9cd72025-01-09T10:29:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14850071485007Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and EvodiamineGuanhua Fang0Guanhua Fang1Yanming Shen2Xinyue Gao3Lele Yang4An Zhu5Dongshan Liao6Dongshan Liao7Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaHeart Center of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaHeart Center of Fujian Medical University, Fuzhou, Fujian, ChinaRecent research has demonstrated the efficacy of traditional Chinese medicine (TCM) and its active compounds in combating cancer, leading to an increasing utilization of TCM as adjunctive therapy in clinical oncology. However, the optimal dosage of TCM remains unclear, and excessive use may result in cardiotoxicity, which poses a significant health concern for patients undergoing systemic treatment. Therefore, elucidating the underlying mechanisms of cytotoxicity induced by TCM can provide valuable insights for clinical management. In this study, we employed a comprehensive bioinformatics analysis to present sequencing data obtained from AC16 myocardial cells treated with two bioactive derived from botanical drugs: Matrine and Evodiamine. We aim to investigate the dysregulated signaling pathways associated with cardiotoxicity induced by these compounds. Based on our sequencing results, we observed consistent patterns of gene expression and epitranscriptome regulation (m6A and A-to-I modifications) across various drugs-treated AC16 cells when analyzed using KEGG pathway enrichment and gene ontology analyses. Furthermore, m6A writers VIRMA and A-to-I writers ADARB1 is consistent target of Evodiamine and Matrine. In general, our findings suggest that different Chinese botanical drugs induced cardiotoxicity may share common therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fphar.2024.1485007/fullm6A (N6-methyladenose)Matrine (M)Evodiamine (evo)cardiotoxicityRNA editing |
| spellingShingle | Guanhua Fang Guanhua Fang Yanming Shen Xinyue Gao Lele Yang An Zhu Dongshan Liao Dongshan Liao Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine Frontiers in Pharmacology m6A (N6-methyladenose) Matrine (M) Evodiamine (evo) cardiotoxicity RNA editing |
| title | Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine |
| title_full | Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine |
| title_fullStr | Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine |
| title_full_unstemmed | Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine |
| title_short | Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine |
| title_sort | consistent rna expression and rna modification patterns in cardiotoxicity induced by matrine and evodiamine |
| topic | m6A (N6-methyladenose) Matrine (M) Evodiamine (evo) cardiotoxicity RNA editing |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1485007/full |
| work_keys_str_mv | AT guanhuafang consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT guanhuafang consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT yanmingshen consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT xinyuegao consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT leleyang consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT anzhu consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT dongshanliao consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine AT dongshanliao consistentrnaexpressionandrnamodificationpatternsincardiotoxicityinducedbymatrineandevodiamine |