Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells

Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells

This study investigated the molecular mechanism of phenotypic switching of vascular smooth muscle cells (VSMCs), which play a crucial role in vascular remodeling using 9H-Carbazol-3-yl 4-aminobenzoate (CAB). CAB significantly attenuated platelet-derived growth factor (PDGF)-induced VSMC proliferatio...

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Bibliographic Details
Main Authors: Joo-Hui Han, Jong-Beom Heo, Hyung-Won Lee, Min-Ho Park, Jangmi Choi, Eun Joo Yun, Seongpyo Lee, Gyu Yong Song, Chang-Seon Myung
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Atherosclerosis
Vascular smooth muscle cell
Signal transducer and activator of transcription 3
Cytokine induced apoptosis inhibitor 1
Janus tyrosine kinase 2
Phenotyping switching
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004921
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