Downregulation of tRNA methyltransferase FTSJ1 by PM2.5 promotes glycolysis and malignancy of NSCLC via facilitating PGK1 expression and translation

Downregulation of tRNA methyltransferase FTSJ1 by PM2.5 promotes glycolysis and malignancy of NSCLC via facilitating PGK1 expression and translation

Abstract Fine particulate matter (PM2.5) exposure has been associated with increased incidence and mortality of lung cancer. However, the molecular mechanisms underlying PM2.5 carcinogenicity remain incompletely understood. Here, we identified that PM2.5 suppressed the expression of tRNA methyltrans...

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Main Authors: Yiling Wang, Yuxin Wen, Qianqian Chen, Yongyi Huang, Duanyang Zhou, Wenhan Yang, Lin Yang, Juan Xiong, Kaiping Gao, Liyuan Sun, Rihong Zhai
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07287-0
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https://doi.org/10.1038/s41419-024-07287-0

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