Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD
Abstract This study aimed to evaluate the changes in cytokine levels in the aqueous humor and factors of treatment resistance following intravitreal faricimab injection in treatment-naïve patients with neovascular age-related macular degeneration. A total of 32 eyes were analyzed before and after a...
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| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83473-6 |
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| author | Ryo Nonogaki Hikaru Ota Jun Takeuchi Yuyako Nakano Ai Fujita Sajiki Takahito Todoroki Koichi Nakamura Hiroki Kaneko Koji M. Nishiguchi |
| author_facet | Ryo Nonogaki Hikaru Ota Jun Takeuchi Yuyako Nakano Ai Fujita Sajiki Takahito Todoroki Koichi Nakamura Hiroki Kaneko Koji M. Nishiguchi |
| author_sort | Ryo Nonogaki |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the changes in cytokine levels in the aqueous humor and factors of treatment resistance following intravitreal faricimab injection in treatment-naïve patients with neovascular age-related macular degeneration. A total of 32 eyes were analyzed before and after a single faricimab injection. Although the best-corrected visual acuity (BCVA) showed no significant improvement, the mean central retinal thickness decreased significantly by 73.7% (P < 0.01), and more than 90% of the eyes showed improvement in exudative changes 1 month after faricimab injection. Moreover, the aqueous humor concentrations of vascular endothelial growth factor (VEGF)-A, angiopoietin (Ang)-2, and placental growth factor considerably decreased 1 month after faricimab injection. Multivariate analyses adjusted for age, sex, BCVA, central choroidal thickness, and aqueous humor cytokines revealed that higher Ang-2 levels in the aqueous humor at baseline were associated with better treatment response to faricimab injection. These findings suggest that the dual inhibition of VEGF-A and Ang-2 by faricimab is effective in reducing exudative changes and that Ang-2 may serve as a potential biomarker for predicting faricimab treatment response. |
| format | Article |
| id | doaj-art-be3adb61ecc9496cb19e2cb0b09ea266 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-be3adb61ecc9496cb19e2cb0b09ea2662025-01-05T12:23:43ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-83473-6Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMDRyo Nonogaki0Hikaru Ota1Jun Takeuchi2Yuyako Nakano3Ai Fujita Sajiki4Takahito Todoroki5Koichi Nakamura6Hiroki Kaneko7Koji M. Nishiguchi8Department of Ophthalmology, Nagoya University Graduate School of MedicineDepartment of Ophthalmology, Nagoya University Graduate School of MedicineDepartment of Ophthalmology, Kyorin University School of MedicineDepartment of Ophthalmology, Nagoya University Graduate School of MedicineDepartment of Ophthalmology, Nagoya University Graduate School of MedicineDepartment of Ophthalmology, Nagoya University Graduate School of MedicineDepartment of Ophthalmology, Nagoya University Graduate School of MedicineDepartment of Ophthalmology, Hamamatsu University School of MedicineDepartment of Ophthalmology, Nagoya University Graduate School of MedicineAbstract This study aimed to evaluate the changes in cytokine levels in the aqueous humor and factors of treatment resistance following intravitreal faricimab injection in treatment-naïve patients with neovascular age-related macular degeneration. A total of 32 eyes were analyzed before and after a single faricimab injection. Although the best-corrected visual acuity (BCVA) showed no significant improvement, the mean central retinal thickness decreased significantly by 73.7% (P < 0.01), and more than 90% of the eyes showed improvement in exudative changes 1 month after faricimab injection. Moreover, the aqueous humor concentrations of vascular endothelial growth factor (VEGF)-A, angiopoietin (Ang)-2, and placental growth factor considerably decreased 1 month after faricimab injection. Multivariate analyses adjusted for age, sex, BCVA, central choroidal thickness, and aqueous humor cytokines revealed that higher Ang-2 levels in the aqueous humor at baseline were associated with better treatment response to faricimab injection. These findings suggest that the dual inhibition of VEGF-A and Ang-2 by faricimab is effective in reducing exudative changes and that Ang-2 may serve as a potential biomarker for predicting faricimab treatment response.https://doi.org/10.1038/s41598-024-83473-6Neovascular age-related macular degenerationFaricimabAnti-vascular endothelial growth factorAngiopoietin-2Analysis in aqueous humor |
| spellingShingle | Ryo Nonogaki Hikaru Ota Jun Takeuchi Yuyako Nakano Ai Fujita Sajiki Takahito Todoroki Koichi Nakamura Hiroki Kaneko Koji M. Nishiguchi Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD Scientific Reports Neovascular age-related macular degeneration Faricimab Anti-vascular endothelial growth factor Angiopoietin-2 Analysis in aqueous humor |
| title | Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD |
| title_full | Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD |
| title_fullStr | Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD |
| title_full_unstemmed | Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD |
| title_short | Analysis of the aqueous humor before and after the administration of faricimab in patients with nAMD |
| title_sort | analysis of the aqueous humor before and after the administration of faricimab in patients with namd |
| topic | Neovascular age-related macular degeneration Faricimab Anti-vascular endothelial growth factor Angiopoietin-2 Analysis in aqueous humor |
| url | https://doi.org/10.1038/s41598-024-83473-6 |
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