Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors

Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors

Abstract Epigenetic targeting of the Hedgehog (HH) signaling pathway has emerged as a possible strategy to combat HH pathway‐driven cancers. In this study, we report on benzo[cd]indol‐2(1H)‐ones as downstream Hedgehog pathway inhibitors. We find that benzo[cd]indol‐2(1H)‐one 1 has sub‐micromolar pot...

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Bibliographic Details
Main Authors: Dr. Ioannis A. Tsakoumagkos, Quentin T. L. Pasquer, Christian‐Louis Guillod, Dr. Charlotte Rossion, Dr. Meropi Bagka, Sonya Torche, Dr. Tomoyo Sakata‐Kato, Prof. Dr. James K. Chen, Prof. Dr. Sascha Hoogendoorn
Format: Article
Language:English
Published: Wiley-VCH 2025-05-01
Series:ChemistryOpen
Subjects:
Hedgehog pathway inhibitor
BET bromodomains
photoaffinity labeling
target identification
mechanism-of-action studies
Online Access:https://doi.org/10.1002/open.202500119
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https://doi.org/10.1002/open.202500119

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