S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis

S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis

Abstract Nitric oxide (NO), a versatile bio-active molecule modulates cellular functions through diverse mechanisms including S-nitrosylation of proteins. Herein, we report S-nitrosylation of selected cysteine residues of EZH2 in endothelial cells, which interplays with its stability and functions....

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Main Authors: Ashima Sakhuja, Ritobrata Bhattacharyya, Yash Tushar Katakia, Shyam Kumar Ramakrishnan, Srinjoy Chakraborty, Hariharan Jayakumar, Shailesh Mani Tripathi, Niyati Pandya Thakkar, Sumukh Thakar, Sandeep Sundriyal, Shibasish Chowdhury, Syamantak Majumder
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59003-x
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https://doi.org/10.1038/s41467-025-59003-x

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