PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling

PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling

Abstract Background Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors. Specifically, PHGDH expression is dynamically regulated during different stages of tumor progression, prom...

Full description

Saved in:
Bibliographic Details
Main Authors: Caterina Mancini, Giulia Lori, Gianluca Mattei, Marta Iozzo, Dayana Desideri, Fabio Cianchi, Laura Fortuna, Federico Passagnoli, Daniela Massi, Filippo Ugolini, Luca Messerini, Salvatore Piscuoglio, Antonio Pezone, Francesca Magherini, Alessio Biagioni, Tiziano Lottini, Demetra Zambardino, Giuseppina Ivana Truglio, Elena Petricci, Alberto Magi, Annarosa Arcangeli, Luisa Maresca, Barbara Stecca, Erica Pranzini, Maria Letizia Taddei
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Phosphoglycerate dehydrogenase
Chemo-resistance
5-Fluorouracil
Colorectal cancer
Serine
Stemness
Online Access:https://doi.org/10.1186/s13046-025-03447-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13046-025-03447-y

Similar Items