Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma
Background: Ameloblastoma is a benign odontogenic neoplasm with a high recurrence rate. Identifying cellular and molecular changes in this neoplasm may help predict the recurrence risk. Bcl-2 and galectin-3 are anti-apoptotic proteins associated with the prognosis of many neoplasms. However, there a...
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| Format: | Article |
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| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Dental Research Journal |
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| Online Access: | https://journals.lww.com/10.4103/drj.drj_706_23 |
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| collection | DOAJ |
| description | Background:
Ameloblastoma is a benign odontogenic neoplasm with a high recurrence rate. Identifying cellular and molecular changes in this neoplasm may help predict the recurrence risk. Bcl-2 and galectin-3 are anti-apoptotic proteins associated with the prognosis of many neoplasms. However, there are a few studies focusing on the association between these two markers and recurrence of ameloblastoma. This study aimed to investigate the association of Bcl-2 plus galectin-3 expression and recurrence of ameloblastoma.
Materials and Methods:
This retrospective cross-sectional study was designed on 48 paraffin-embedded blocks diagnosed as ameloblastoma from 1998 to 2019. We retrieved follow-up data from patients’ records and used immunohistochemical staining for Bcl-2 and galectin-3 antibodies. Then, we analyzed their association with recurrence using Chi-square and Mann–Whitney test as well as recurrence-free survival using Kaplan–Meier curves and linear Cox regression. The level of statistical significance was P < 0.05.
Results:
Twenty-six patients had experienced the recurrence. The mean follow-up time was 93.53 months. There was a significant association between Bcl-2 plus cytoplasmic galectin-3 staining and recurrence (both P < 0.001). Furthermore, in univariate analysis, high expression of Bcl-2 was associated with less recurrence-free survival (log-rank: P = 0.020-univariable Cox: P = 0.033), but in multiple Cox regression, there was no significant association (P = 0.471). High cytoplasmic galectin-3 expression was also associated with less recurrence-free survival (log-rank: P = 0.007-univariable Cox: P = 0.015-multiple Cox: P = 0.044). Furthermore, we found a correlation between Bcl-2 and cytoplasmic galectin-3 staining (P = 0.001).
Conclusion:
It seems that Bcl-2 and cytoplasmic galectin-3 staining might predict the risk of ameloblastoma recurrence. However, only the cytoplasmic galectin-3 staining might be an independent predictor of ameloblastoma recurrence, and we recommend further studies. |
| format | Article |
| id | doaj-art-bdc1ddc007b742d98284aa575dff012e |
| institution | Kabale University |
| issn | 1735-3327 2008-0255 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj-art-bdc1ddc007b742d98284aa575dff012e2025-01-08T10:19:32ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552024-12-01211696910.4103/drj.drj_706_23Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastomaBackground: Ameloblastoma is a benign odontogenic neoplasm with a high recurrence rate. Identifying cellular and molecular changes in this neoplasm may help predict the recurrence risk. Bcl-2 and galectin-3 are anti-apoptotic proteins associated with the prognosis of many neoplasms. However, there are a few studies focusing on the association between these two markers and recurrence of ameloblastoma. This study aimed to investigate the association of Bcl-2 plus galectin-3 expression and recurrence of ameloblastoma. Materials and Methods: This retrospective cross-sectional study was designed on 48 paraffin-embedded blocks diagnosed as ameloblastoma from 1998 to 2019. We retrieved follow-up data from patients’ records and used immunohistochemical staining for Bcl-2 and galectin-3 antibodies. Then, we analyzed their association with recurrence using Chi-square and Mann–Whitney test as well as recurrence-free survival using Kaplan–Meier curves and linear Cox regression. The level of statistical significance was P < 0.05. Results: Twenty-six patients had experienced the recurrence. The mean follow-up time was 93.53 months. There was a significant association between Bcl-2 plus cytoplasmic galectin-3 staining and recurrence (both P < 0.001). Furthermore, in univariate analysis, high expression of Bcl-2 was associated with less recurrence-free survival (log-rank: P = 0.020-univariable Cox: P = 0.033), but in multiple Cox regression, there was no significant association (P = 0.471). High cytoplasmic galectin-3 expression was also associated with less recurrence-free survival (log-rank: P = 0.007-univariable Cox: P = 0.015-multiple Cox: P = 0.044). Furthermore, we found a correlation between Bcl-2 and cytoplasmic galectin-3 staining (P = 0.001). Conclusion: It seems that Bcl-2 and cytoplasmic galectin-3 staining might predict the risk of ameloblastoma recurrence. However, only the cytoplasmic galectin-3 staining might be an independent predictor of ameloblastoma recurrence, and we recommend further studies.https://journals.lww.com/10.4103/drj.drj_706_23ameloblastomaapoptosisbcl-2 proteingalectin 3recurrence |
| spellingShingle | Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma Dental Research Journal ameloblastoma apoptosis bcl-2 protein galectin 3 recurrence |
| title | Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma |
| title_full | Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma |
| title_fullStr | Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma |
| title_full_unstemmed | Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma |
| title_short | Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma |
| title_sort | bcl 2 and galectin 3 expression is associated with recurrence of ameloblastoma |
| topic | ameloblastoma apoptosis bcl-2 protein galectin 3 recurrence |
| url | https://journals.lww.com/10.4103/drj.drj_706_23 |