A randomized controlled trial comparing romosozumab and denosumab in elderly women with primary osteoporosis and knee osteoarthritis

A randomized controlled trial comparing romosozumab and denosumab in elderly women with primary osteoporosis and knee osteoarthritis

Abstract We compared the efficacy of romosozumab and denosumab in elderly women with primary osteoporosis and knee osteoarthritis in a randomized controlled trial. A total of 112 participants aged 75–90 years were randomized equally into the romosozumab and denosumab groups. Among these, 49 and 52 p...

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Main Authors: Yasumori Sobue, Hironobu Kosugiyama, Shuji Asai, Yoshikazu Ogawa, Minoru Yoneda, Koji Maruyama, Mariko Kaneko, Tomonori Kobayakawa, Kenya Terabe, Mochihito Suzuki, Ryo Sato, Yusuke Ohno, Junya Hasegawa, Takaya Sugiura, Masahiko Ando, Yachiyo Kuwatsuka, Naoki Ishiguro, Shiro Imagama
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Denosumab
Knee osteoarthritis
Osteophyte
Osteoporosis
Romosozumab
Online Access:https://doi.org/10.1038/s41598-025-05187-7
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https://doi.org/10.1038/s41598-025-05187-7

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