[18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency
Minimally invasive parathyroidectomy is the treatment of choice in patients with primary hyperparathyroidism (PHP), but it needs a reliable preoperative localization method to detect hyperfunctioning parathyroid tissue. Higher sensitivity and lower radiation exposure was demonstrated for [18F]fluoro...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2024-11-01
|
| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2024-0058 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556525193101312 |
|---|---|
| author | Rep Sebastijan Sirca Klara Lezaic Ema Macek Zaletel Katja Hocevar Marko Lezaic Luka |
| author_facet | Rep Sebastijan Sirca Klara Lezaic Ema Macek Zaletel Katja Hocevar Marko Lezaic Luka |
| author_sort | Rep Sebastijan |
| collection | DOAJ |
| description | Minimally invasive parathyroidectomy is the treatment of choice in patients with primary hyperparathyroidism (PHP), but it needs a reliable preoperative localization method to detect hyperfunctioning parathyroid tissue. Higher sensitivity and lower radiation exposure was demonstrated for [18F]fluorocholine PET/CT (FCh-PET/CT) in comparison to [99mTc]sestamibi (MIBI) scintigraphy. However, data of its efficiency in resource use and patient outcomes is lacking. The aim of our study was to determine the resource efficiency and patient outcomes of FCh-PET/CT in comparison to conventional MIBI scintigraphy. |
| format | Article |
| id | doaj-art-bd6e12e5156c405c93de053a45612184 |
| institution | Kabale University |
| issn | 1581-3207 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj-art-bd6e12e5156c405c93de053a456121842025-01-07T07:56:43ZengSciendoRadiology and Oncology1581-32072024-11-0158448649310.2478/raon-2024-0058[18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiencyRep Sebastijan0Sirca Klara1Lezaic Ema Macek2Zaletel Katja3Hocevar Marko4Lezaic Luka5Division of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Oncological Surgery, Institute of Oncology Ljubljana, Ljubljana, SloveniaCharité Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, GermanyDivision of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Oncological Surgery, Institute of Oncology Ljubljana, Ljubljana, SloveniaDivision of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaMinimally invasive parathyroidectomy is the treatment of choice in patients with primary hyperparathyroidism (PHP), but it needs a reliable preoperative localization method to detect hyperfunctioning parathyroid tissue. Higher sensitivity and lower radiation exposure was demonstrated for [18F]fluorocholine PET/CT (FCh-PET/CT) in comparison to [99mTc]sestamibi (MIBI) scintigraphy. However, data of its efficiency in resource use and patient outcomes is lacking. The aim of our study was to determine the resource efficiency and patient outcomes of FCh-PET/CT in comparison to conventional MIBI scintigraphy.https://doi.org/10.2478/raon-2024-0058hyperparathyroidismsurgeryparathyroidectomycost-effectiveness[18f]choline[99mtc]sestamibipet/ctspect/ct |
| spellingShingle | Rep Sebastijan Sirca Klara Lezaic Ema Macek Zaletel Katja Hocevar Marko Lezaic Luka [18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency Radiology and Oncology hyperparathyroidism surgery parathyroidectomy cost-effectiveness [18f]choline [99mtc]sestamibi pet/ct spect/ct |
| title | [18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency |
| title_full | [18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency |
| title_fullStr | [18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency |
| title_full_unstemmed | [18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency |
| title_short | [18F]fluorocholine PET vs. [99mTc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency |
| title_sort | 18f fluorocholine pet vs 99mtc sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism outcomes and resource efficiency |
| topic | hyperparathyroidism surgery parathyroidectomy cost-effectiveness [18f]choline [99mtc]sestamibi pet/ct spect/ct |
| url | https://doi.org/10.2478/raon-2024-0058 |
| work_keys_str_mv | AT repsebastijan 18ffluorocholinepetvs99mtcsestamibiscintigraphyfordetectionandlocalizationofhyperfunctioningparathyroidglandsinpatientswithprimaryhyperparathyroidismoutcomesandresourceefficiency AT sircaklara 18ffluorocholinepetvs99mtcsestamibiscintigraphyfordetectionandlocalizationofhyperfunctioningparathyroidglandsinpatientswithprimaryhyperparathyroidismoutcomesandresourceefficiency AT lezaicemamacek 18ffluorocholinepetvs99mtcsestamibiscintigraphyfordetectionandlocalizationofhyperfunctioningparathyroidglandsinpatientswithprimaryhyperparathyroidismoutcomesandresourceefficiency AT zaletelkatja 18ffluorocholinepetvs99mtcsestamibiscintigraphyfordetectionandlocalizationofhyperfunctioningparathyroidglandsinpatientswithprimaryhyperparathyroidismoutcomesandresourceefficiency AT hocevarmarko 18ffluorocholinepetvs99mtcsestamibiscintigraphyfordetectionandlocalizationofhyperfunctioningparathyroidglandsinpatientswithprimaryhyperparathyroidismoutcomesandresourceefficiency AT lezaicluka 18ffluorocholinepetvs99mtcsestamibiscintigraphyfordetectionandlocalizationofhyperfunctioningparathyroidglandsinpatientswithprimaryhyperparathyroidismoutcomesandresourceefficiency |